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NanoBone® product features


Unsintered

All NanoBone® technology products are produced in a sol-gel process at temperatures of up to 700°C. The low temperatures mean the material is not sintered and its surface is therefore highly porous with pores ranging from nanometers to micrometers in size. The autologous proteins from the blood enter the nanopores and cover the entire inner surface. The body accepts NanoBone® as endogenous and the natural remodeling process begins.

Osteoconductive

Harms et al. have demonstrated NanoBone®’s great osteoconductive potential. The augmentation material acts as a conductor. A protein-rich organic matrix forms which promotes the growth of connective tissue.

Osteoinductive

Götz et al. have demonstrated the osteinductive nature of NanoBone®. They were able to prove that osteblasts and osteclasts were attracted and differentiated. Ectopic bone formation was observed in a test with Göttingen minipigs.

What's NanoBone®

NanoBone® technology is a completely new product category, wholly unlike the bone substitute materials previously available on the market. Nanocrystalline hydroxylapatite (HA) is embedded in a silica gel matrix (Si02). The nanocrystaline HA is more or less the same as the autologous HA of the bone. Silica gel promotes the formation of collagen and bone

Nanotechnologies

Produced using a sol gel process at temperatures of up to 700°C, the material is unsintered and has pores ranging from nanometers to micrometers in size. The potential of nanotechnology is harnessed through the nanocrystalline HA and the interconnecting nanopores. The proteins from the blood cover the entre inner surface (approx. 84 m²/g) and the body accepts the biomaterial almost as if it were endogenous.

Exchange matrix

The silica gel matrix becomes an organic matrix within the first two weeks in a process of matrix change. As a result of this process, the NanoBone® granules take on exactly the same characteristics as the extracellular matrix of the bone.

Remodelling

NanoBone® promotes natural remodeling. The attraction and differentiation of the osteblasts and osteclasts is a strong indiciation of the biomaterial’s osteoinductive properties.